PPARG and diabetic kidney disease: A decrease in podocytenumber in type 2 diabetic Pima Indians correlates closely with those patientswho have microalbuminuria, the earliest manifestation of diabetic nephropathy [37].High-glucose treatment or the epithelial cell toxin puromycin aminonucleosid(PAN) supplementation induces podocyte injury and PPARγ upregulation in podocyte culture [37].