HOXD3 and lung carcinoma: HOXD3 [Homoebox transcription factor] (chromosome # 2q31-37), a gene found to be methylated in lung cancer cell lines and primary tumours [34], which showed a distinct pattern of increasing methylation with tumour grade in our series based on average enrichment difference (6.4), suggesting that methylation of this gene may be involved in disease progression as well.