This draws a direct parallel between the pathogenesis of EBV-positive BL and that seen in mouse models of c-myc-driven lymphomagenesis [23],[24], where the drive towards full malignancy occurs only when a target cell expressing a deregulated c-myc oncogene acquires complementary changes that counteract c-myc-driven apoptosis. Here, MYC is linked to Burkitt lymphoma.