Second, the more connected nodes (hubs with≥5 neighbors, shown in blue in Figure 2) identify the main classes of fusion proteins found in cancer, that is, those involving the tyrosine kinase (TK) domain, the EWS activation domain (EAD), the Runt domain, the ligand binding domain of the nuclear hormone receptor (HRMN), the AT-hook DNA binding domain (HOOK and COIL/HZ), the GLFG repeats (NUP) and coiled coils (COIL). Here, EWSR1 is linked to cancer.