Moreover, it remains to be investigated whether expression of MALT1-API2 also reduces API2-MALT1-mediated NF-κB activation in t(11;18)(q21;q21)-positive MALT lymphomas, for example by analyzing its effect on the Lys63-linked polyubiquitination of IKKγ [23]. Here, MALT1 is linked to MALT lymphoma.