Induction ofPPARγ by 15-LOX metabolites and by COX-2 inhibitors and PPARγ effects on COX-2activity, among other results, are pointing out a cross-talk betweeneffectors of the AA pathway (LOX and COX products) and PPARγ activity.Deregulation of this cross-talk is thought to allow tumor progression. Here, LOX is linked to neoplasm.