LOX and cancer: Given the proinflammatory effects of LTs and their deleterious effectson gastric mucosa,dual inhibition of LOX and COX pathways might improve gastric tolerability [45].On the other hand, free unmetabolized AA may induce a concentration-dependentapoptosis on cancer cells [46].Therefore, blocking LOX/COX pathways simultaneously may prevent recruitment ofalternate pathways within the AA pathway and may lead to an accumulation of AAthat could increase apoptosis induction.