To determine the importance of the CRD in sFRP1 for androgen-dependent prostate cancer cell proliferation, LNCaP cells and a subline of LNCaP, LNCaP-r, which expresses AR but is hormone resistant (Pousette et al, 1997), were transfected with empty vector, sFRP1 or the sFRP1 deletion mutants and grown in medium containing G418. The gene discussed is AR; the disease is Familial prostate cancer.