Secreted Frizzled-related protein-1 expression is downregulated in many cancers including prostate cancer (Ugolini et al, 2001; Suzuki et al, 2002; Caldwell et al, 2004; Klopocki et al, 2004; Stoehr et al, 2004; Takada et al, 2004; Lodygin et al, 2005; Lo et al, 2006; Shih et al, 2006, 2007; Veeck et al, 2006; Dahl et al, 2007; Huang et al, 2007; Nojima et al, 2007). This evidence concerns the gene SFRP1 and prostate cancer.