The sFRP1 gene is inactivated in many human cancers either as a result of chromosomal deletions (Stoehr et al, 2004; Huang et al, 2007) or promoter hypermethylation (Suzuki et al, 2002; Takada et al, 2004; Lodygin et al, 2005; Lo et al, 2006; Shih et al, 2006; Veeck et al, 2006; Dahl et al, 2007; Huang et al, 2007; Nojima et al, 2007), and loss of sFRP1 expression contributes to a poor prognosis (Klopocki et al, 2004; Veeck et al, 2006). Here, SFRP1 is linked to cancer.