Finally, as shown in Figure 8B, we also showed that MAGE-A4 helper epitope peptides were presented to MHC class II molecules on MAGE-A4-specific Th1 cells to stimulate Th1-derived cytokine release, which is preferable to induce IFN-γ-producing Tc1 cells essential for eradication of tumour cells. This evidence concerns the gene MAGEA4 and neoplasm.