PTEN and neoplasm: In agreement with the interplay between the oncogenic signaling and AMPK is the recent finding where the activation of AMPK pathway by administration of metformin, phenformin or A-769662 to PTEN(+/−) mice significantly delayed tumor onset, demonstrating that LKB1 is required for activators of AMPK to inhibit mTORC1 signaling as well as cell growth in PTEN-deficient cells [42].