Although experiments conducted in G361 melanoma cells indicate that this residue is involved in LKB1-mediated cell growth inhibition [8], [23], and several other investigations implicate LKB1Ser431 residue in the activation of AMPK and BRK1/BRSK2 kinases (SAD-B/SAD-A) [21], [24], [25], a recent publication stating that LKB1 phosphorylation in the C-terminal is not required for regulation of AMPK BRSK1/2 and cell cycle arrest contradicts the previous findings [26]. The gene discussed is STK11; the disease is melanoma.