Importantly, inhibition of RAS-Erk1/2 pathway in BRAFV600E mutant melanoma cell lines restores the LKB1-AMPK-mTOR pathway response to metabolic stress promoting apoptosis in coordination with the BH3-family proteins Bad and Bim and the Bcl-2 family member Mcl-1. The gene discussed is PRKAA2; the disease is melanoma.