Experimental measurements of cytokines and hemodynamic parameters suggest the integral role of hypercortisolemia in CORT-LPS and CORT-6-LPS groups in modulating the cytokine network characterized by decreased plasma concentrations of various cytokines, i.e. TNF, IL-6 when compared to the group that received only LPS. The gene discussed is TNF; the disease is adrenal gland hyperfunction.