Polymorphisms in the angiotensinogen gene (M235T and A-20C) have been associated with hypertension [18], [19], faster progression to ESRD [20], susceptibility to nephropathy in patients with type I diabetes mellitus [21], and progression of renal dysfunction in adults [22] and children [23] with IgA nephropathy. The gene discussed is AGT; the disease is type 1 diabetes mellitus.