The beneficial effect could be due to the synergistic effect of a upregulation in antioxidant Bcl-2 and HSP-70 protein, a suppression of endothelial ICAM-1 protein expression, and a reduction in leucocyte and platelet adhesion, consequently leading to the delay of FeCl3 induced thrombus formation in the vascular endothelium of HF fed hamsters. The gene discussed is ICAM1; the disease is hydrops fetalis.