Interestingly, a consensus binding site for NF-κB p65 (TGGAGCTTCC) was found in the 5'-flanking region of the human MT1-MMP gene [48] and NF-κB-mediated induction of MT1-MMP was confirmed in murine melanoma cells [49] and in human fibrosarcoma cells [50]. This evidence concerns the gene NFKB1 and melanoma.