Moreover, the IL6 haplotype H2 was differently distributed between cases and controls (6.2% versus 2.4%, P = 0.0006) and associated with almost 5 times higher risk of COPD compared to the most common haplotype H4 (OR = 4.82, 95%CI 1.64–4.18, P = 0.004) (Table 6). The gene discussed is IL6; the disease is chronic obstructive pulmonary disease.