HPGDS and cancer: Given the importance of GSTs in the detoxification of electrophilic carcinogens, the possible influence of polymorphisms in GST genes on cancer risk has been investigated extensively (Bolufer et al. 2006; Bolt and Thier 2006; Carlsten et al. 2008; Hiyama et al. 2008; Parl 2005; Shi et al. 2008; Vineis et al. 2007; White et al. 2008).