NRGN and bipolar disorder: This gene could be involved in bipolar disorder observed in some JS patients [12].BSX, an evolutionarily highly conserved homeobox gene, expressed during early brain development and mapping in 122.3 Mb has been proposed as a candidate gene for global cognitive development, while NRGN (neurogranin), a gene involved in synapse plasticity and long-term potentiation and mapping in 124.1 Mb has been suggested to contribute to the auditory attention deficit [10].