Another possible reason for the decrease in C2GnT1 mRNA levels that we observed in poorly differentiated colorectal adenocarcinomas is that the tissues used for RT-PCR and those used for immunohistochemistry were from different sources and we could not make a direct correlation between C2GnT1 mRNA levels and C2-O-sLex levels in the same patient. This evidence concerns the gene GCNT1 and colorectal adenocarcinoma.