ACY1 and brain cancer: For example, in brain cancer, because of the alternative splicing and deletion of domain of the peptidase m20 family member, the aminoacylase-1 gene (ACY1) was spliced to produce a brain cancer-specific transcript (Figure 1a), and alternative splicing occurs in the SRP19 gene to produce a breast cancer-specific transcript by an alternative deletion of exon 3 (Figure 1b).