Nevertheless, it may, from the theoreticalpoint of view, still be valuable to study various suppressor genes like P53 and their protein expressions, inthat osteosarcomas are known to occur with higher frequency in persons with impairedor defect suppressor genes like in the case of inherited retinoblastoma [46, 47].Indeed, a recent study has shown prognostic impact of the combined informationregarding protein expression of markers of apoptotic cell death, such as p53,bax, and bcl-2, as compared to missing prognostic value displayed by each ofthese molecules individually [48]. The gene discussed is BCL2; the disease is retinoblastoma.