EFNB2 expression has also been associated with cellular proliferation (Batlle et al. 2002; Steinle et al. 2003), cell migration (Steinle et al. 2003), angiogenesis (Noren et al. 2004) and the progression of a wide range of human cancers, including malignant melanoma (Vogt et al. 1998), small cell lung carcinoma (Tang et al. 1999), osteosarcoma (Varelias et al. 2002), endometrial cancer (Takai et al. 2001), colon/colorectal carcinoma (Liu et al. 2004) and breast cancer (Noren et al. 2004). Here, EFNB2 is linked to osteosarcoma.