Located on chromosome 20q11, TPX2 is amplified in giant-cell tumor of the bone(58), and is overexpressed in squamous cell lung cancer(43), neuroblastoma(37), poor prognosis breast cancer(53,67) and endometrial cancer, where its expression level is correlated with stage, grade, and myometrial invasion(8). This evidence concerns the gene TPX2 and bone giant cell tumor.