There are many examples of genes that undergo amplifications in cancer, including AKT2 in ovarian cancer, ERRB2 in breast and ovarian cancer, MYCL1 in small cell lung cancer, MYCN in neuroblastoma and EGFR in glioma and non-small cell lung cancer; a comprehensive account of these and other cancer-related genes can be found in Futreal et al. (2004). The gene discussed is ESRRB; the disease is cancer.