CDH1 and neoplasm: In some tumor types and cellular models, loss of E-cadherin associates to the process known as Epithelial-Mesenchymal Transition (EMT), which is characterized by up-regulation of mesenchymal markers (vimentin, fibronectin), modification of actin cytoeskelton (induction of stress fibers and focal adhesions), and acquisition of a fibroblastic, highly invasive and metastatic phenotype [17,18].