Our results also do not offer support for the possibility that the increase in infectivity of several viruses observed in target cells treated with low-dose Debio-025 resulted from inhibition of the activity of TRIM5α, because TRIM5α mRNA expression was quite similar for cell types in which infection with a given virus did or did not display biphasic dose response curves in response to CypA inhibitors. This evidence concerns the gene PPIA and infection.