Immunization of mice with M3-protein leads to the formation of CIV auto-antibodies, which are also found in the sera of patients with ARF or RHD [6] and our group has shown previously that collagen-binding M-proteins like the M3-protein bind and aggregate CIV via an octa-peptide motif that is referred to as PARF (peptide associated with rheumatic fever) [5]. This evidence concerns the gene MYOM2 and rheumatic fever.