HNF1A and pancreatic insulinoma: To better understand the molecular events associatedwith PTDM we investigated the effect of cyclosporine on expression and activityof hepatic nuclear factor (HNF)1alpha and 4alpha and on genes coding for glucosemetabolism in cultures of the rat insulinoma cell line INS-1E, the humanepithelial cell line Caco-2 and with Zucker diabetic fatty (ZDF) rats.