Mutations in the gene encoding the laminin β2 subunit (LAMB2 (150325)) have been found to be responsible for Pierson syndrome (MIM 609049), which is characterised by congenital nephrosis and ocular defects.10 The majority of the reported LAMB2 defects are truncation mutations, which result in a complete lack of laminin β2 immunoreactivity in the glomerular basal membrane as well as a severe phenotype that leads to death within days or months after birth.10 Here, LAMB2 is linked to congenital nephrotic syndrome, Finnish type.