Interestingly, elevated p62 levels have been reported in model systems of neurodegenerative diseases including Huntington's disease (Gal et al., 2007; Nagaoka et al., 2004), and this may be sufficiently high to contribute to the accumulation of ubiquitinated substrates that has been recently reported in this condition (Bennett et al., 2007). The gene discussed is SQSTM1; the disease is Huntington disease.