The Dystroglycan-Dystrophin (Dg-Dys) complex has been shown to provide cells with structural integrity by forming a conduit between the extracellular matrix and the cytoskeletal network and there are lines of evidence that implicate an additional signaling role for the complex [1,2] Dystroglycan binds to extracellular matrix components, including Laminin at its N-terminus and the actin cytoskeleton via Dystrophin at its C-terminus [3,4] Defects in these interactions can result in muscular dystrophies (MD) and various epithelial cancers [5]. The gene discussed is DAG1; the disease is muscular dystrophy.