GH1 and Alzheimer disease: The mostdramatic of these includes suppression of metabolic rate, reduction of thyroidhormone levels and growth hormone levels, suppression of gonadal function, andan increased activation of the hypothalamic-pituitary-adrenal axis[99,105].As discussed in the next section, aging individuals and especially individualswith AD exhibit increased incidence of each of these physiological alterations[68,106].Ostensibly aging humans in the environment of evolutionary adaptedness wouldhave benefited from the same physiological alterations as starving animals.