Interestingly, we noticed that one-third of the CpG islands identified by microarray analysis (26 out of the 81 annotated hits) are associated with members of various homeobox superfamilies (HOX, LHX, NKX, PAX, and so forth) and are preferential targets of de novo methylation in early-stage breast cancer. The gene discussed is RAB2A; the disease is breast carcinoma.