Finally, in an attempt to support our premise that ING4 downregulation may contribute to lung fibrosis and lead to more progressive disease stages, we have demonstrated that ING4 semi-quantitative expression levels are negatively associated with markers of disease prognosis including pulmonary function parameters such as FVC, TLC and KCO, as shown in Figure 5(A, B) and 5(C) respectively. Here, ING4 is linked to pulmonary fibrosis.