For intragroup comparison, significantly higher expressions of PI3K, pAkt, pmTOR, and p4E-BP1 and lower expression of PTEN were observed in nasal polyps compared to the control in the absence of rapamycin stimulation (P < 0.05 by the unpaired t-test) (Figure 4A, B). This evidence concerns the gene EIF4EBP1 and Nasal polyposis.