After rapamycin treatment, a slight decrease in Th1 and Th2 cytokines, IFN-γ, IL-4, and IL-5 (30%, 47%, and 41%, respectively;P > 0.05 by the paired t-test), and a significant increase in IL-10 was found in nasal polyps compared to the untreated polyp tissues (4.4-fold; P < 0.05 by the paired t-test). The gene discussed is IL5; the disease is Nasal polyposis.