In order to evaluate the possible association between inhibition of mTOR signaling and Foxp3+ Treg expansion, we investigated a series of proteins, including PTEN, PI3K, pAkt, pmTOR, p4E-BP1, T-bet, GATA-3, and Foxp3 in rapamycin-stimulated nasal polyps by western blot analysis. This evidence concerns the gene PTEN and Nasal polyposis.