Furthermore, Foxp3 expression was significantly upregulated (3.3-fold in nasal polyps and 2.3-fold in control tissues; P < 0.05 by the paired t-test) after rapamycin stimulation, while T-bet and GATA-3 expression decreased correspondingly (P < 0.05 by the paired t-test). This evidence concerns the gene GATA3 and Nasal polyposis.