Normal control and PS-1 (M146L) AD human skin fibroblasts were stimulated for 0–30 min with BK concentrations of 25 or 250 nM, which respectively target the I (intermediate) and L (low) affinity phosphorylated BKB2R forms we previously characterized in AD fibroblasts [12], [13], [39], [40]. This evidence concerns the gene KNG1 and Alzheimer disease.