LMNA and muscular dystrophy: In agreement with this notion, patients with FSHD display some clinical and transcriptional resemblances to Emery-Dreifuss, a muscular dystrophy linked to mutation in the LMNA gene [44], suggesting that the affinity of D4Z4 for A-type lamins might contribute to the epigenetic regulation of the 4q35 locus by providing the proper subnuclear environment for the regulation of the gene(s) causing the dystrophy.