It is important to note that, at the time of writing, these newer data have not yet been incorporated into the CORE diabetes model, so the potentially negative effect of more intensive treatments is not considered; only information from the ADVANCE trial was used as the reference for the current management of diabetic patients in the use of aspirin, statins, and angiotensin receptor blocker (ARB)/angiotensin-converting enzyme (ACE) inhibitors. This evidence concerns the gene ACE and diabetes mellitus.