PLAAT4 and melanoma: Recently, dodecapeptides (DPs) H-TIG-3111–123 and H-Ha-Rev107-1111–123, based on 12 conserved amino acids surrounding the NC motif within the NC domain of RIG1 and HREV107, have been shown to induce apoptosis of melanoma cells, and the Leu120 has been shown to be indispensable for this activity [22].