A recent GWA scan in 1,000 US Caucasians with measures available on BMI and fat mass, identified two novel obesity gene loci in the proximity of FDFT1 (farnesyl-diphosphate farnesyltransferase 1) and CTNNBL1 (catenin (cadherin-associated protein), β-like 1) [16]. The gene discussed is FDFT1; the disease is obesity due to melanocortin 4 receptor deficiency.