On the basis of biochemical or physiological functions, genetic variants of angiotensin converting enzyme, angiotensinogen (AGT), angiotensin type 1 receptor, aldosterone synthase (CYP11B2), adducin, renin of RAAS have been intensively studied in various populations with conflicting results in relation to hypertension [3], diabetic complications [4], coronary heart disease [5] and renal disease [6]. The gene discussed is REN; the disease is hypertensive disorder.