In addition to slower proliferation, we find a specific and strong increase in apoptotic cell death, as measured by annexin-V and cleaved caspase-3 (ENST00000308394), in MCC (MCC14.2 series) and CRC (Ht29) cell lines transduced or transfected with Atoh1 (Figures 6A, 6B, and S10B). This evidence concerns the gene ANXA5 and Merkel cell skin cancer.