In order toidentify motor proteins involved in lysosomal trafficking in cancer cells, wecompared the proteomes of lysosomes isolated from control MCF-7 andMCF-7-ΔNErbB2 cells by stable-isotope labeling by amino acids(Lys0/Lys8) in cell culture (SILAC) followed by mass spectrometry analysis [22].Six myosin motors and one microtubule specific kinesin motor could be detectedby this approach as lysosome-associated motor proteins (Table 1 and DatasetS1). The gene discussed is MYH14; the disease is cancer.