We have recently shown that vincristine, a compound thatdestabilizes microtubules and is frequently used in cancer therapy, induce dramaticaggregations of lysosomes and induces LMP and death in HeLa cells [10].The two treatments might have similar consequences for lysosomal distributionresulting in lysosomes that are brought together in an uncontrolled manner inducingaggregations and subsequent destabilization of lysosomes resulting in death. The gene discussed is PDLIM7; the disease is cancer.