The minor allele frequencies of two coding SNPs were significantly over-represented in MDS cases vs. race-matched controls: rs3734166 (CDC25C R70C) (OR 1.836, 95% conf 1.030–3.272, p = 0.048), and rs2905608 (KLHL3 A157A) (OR 99.47, 95% conf 5.914–1673, p = 2.187E-10). Here, KLHL3 is linked to myelodysplastic syndrome.