PIK3CA and breast cancer: BRAF, ERBB2, KRAS and PIK3CA are all oncogenes shown to be involved in OC development, and NMI interacts with the oncogenes NMYC, MYC, MAX and FOS. NMI has also been shown to form a complex with MYC and BRCA1 and therefore may play a role in breast cancer and OC (Li et al, 2002).