SPP1 and prostate cancer: αvβ3 is a candidate integrin for assisting in metastasis of prostate cancer to bone.[29, 30] Prostate cancer cell adhesion and migration in dominant components of the bone matrix, such as osteopontin and vitronectin, are mediated by αvβ3.[31] Antibodies blocking αvβ3 integrin have been shown to reduce prostate cancer cell adhesion to bone protein extracts by 94%.[31] Edlund et al., showed that LNCaP cells had undetectable levels of αvβ3 but that metastatic-derived cells from LNCaP cells showed consistent expression of this integrin.