TWF1 and Familial prostate cancer: In some neoplasms, α2β1 expression has been associated with tumor progression and metastasis.[27] Bonkhoff et al., evaluated 33 prostatectomy specimens and 10 metastatic lymph nodes using immunohistochemical.[28] They found preserved or increased α6 expression and down-regulation of α2 expression in low-grade prostate cancer and decreased expression for both in high-grade tumors.