Recently, an essential role for Siva-1 was also shown in campotheticin-induced apoptosis in cerebellar neuronal granules, that was also p53 dependent.[23] The fact that expression of Siva-1 can potentiate cisplatin-induced apoptosis even in the absence of a functional p53 means that Siva-1 is likely to play a role in genotoxic stress-induced apoptosis, even if p53 is mutated and non-functional, as is the case with almost 50% of cancers. This evidence concerns the gene SIVA1 and cancer.