8 of 18 (44%) well differentiated HCC tissues, 39 of 60 (65%) moderately differentiated HCCs, and 15 of 17 (88%) poorly differentiated HCCs were positive for Cav-1 (Table 2), indicating that Cav-1 expression is also closely related to differentiation status of primary HCC tumors (p = 0.001). Here, CAV1 is linked to hepatocellular carcinoma.