When we analyzed differentiation status of these HCC cell lines according to HNF1α, 3α, 3β, 4α and 6 expressions, HepG2, Hep3B, PLC/PRF-5 and Huh7 formed a group of well differentiated cell lines, whereas others formed another subgroup of poorly differentiated cell lines (E. Erdal et al.; unpublished data). Here, HNF1A is linked to hepatocellular carcinoma.