Especially the Insulin-like Growth Factor (IGF-1/IGF-1R), Hepatocyte Growth Factor (HGF/MET), Wnt (Wnt/FZD), Transforming Growth Factor-alpha/Epidermal Growth Factor (TGF-α/EGF/EGFR) and Transforming Growth Factor-beta (TGF-β/TGF-βR) pathways contribute to proliferation, antiapoptosis and invasive behavior of hepatocellular carcinoma cells [1-4]. This evidence concerns the gene EGF and hepatocellular carcinoma.