In conclusion, no effect of ABCG1 over-expression was seen in hippocampal synaptic plasticity and behavioural parameters such as anxiety and general locomotor activity, or on learning and memory, suggesting that despite changes in cholesterol flux in brain, it is unlikely that over-expression of ABCG1 contributes to cognitive deficits in the DS population. The gene discussed is ABCG1; the disease is Cognitive impairment.