MET and cancer: Owing to the unique intrinsic properties of MET regulating cellular ‘invasive signalling’, MET has been proposed as not merely playing a role in ‘oncogene addiction’ in a small subset of human cancers but can also play an essential role in ‘oncogene expedience’ by inducing an enhanced transformed tumour malignant ‘fitness’ in a much larger range of cancers leading to promotion of tumour progression (Comoglio et al, 2008).