Furthermore, using a combination of small-molecule kinase inhibitors and short-interfering RNA (siRNA), we examined the role of MET inhibition, either alone or combined with EGFR inhibition, using both in vitro and in vivo assays against the EGFR-TKI-resistant lung cancer cell line H1975 (L858R/T790M-mutant EGFR). This evidence concerns the gene EGFR and lung cancer.