In particular, it inhibited MET signalling, induced cellular apoptosis, and abrogated cytoskeletal functions (key controlling step in tumour invasion and metastasis) in vitro (Birchmeier et al, 2003), and was effective in vivo, leading to cytoreduction of murine tumour xenografts of the T790M-EGFR expressing erlotinib-resistant H1975 cells. The gene discussed is EGFR; the disease is neoplasm.