ERED needs to be differentiated from other conditions that are accompanied by recurrent epithelial erosions, particularly when they are the initial presenting manifestations early in life, such as epithelial basement membrane dystrophy, MECD, RBCD, TBCD, SMCD, LCD1, GCD1, GCD2, and MCD. The gene discussed is TGFBI; the disease is Reis-Bücklers corneal dystrophy.