CYP1B1 mutations are also present in certain families where PCG and primary open-angle glaucoma (POAG) coexist [5,21,23], in non-Mendelian POAG cases [24-26], and in monogenic anterior segment dysgenesis like Peters’ anomaly [27,28] and Rieger’s anomaly [29]. The gene discussed is CYP1B1; the disease is open-angle glaucoma.